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KMID : 1140120080130020081
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Cancer Prevention Research
2008 Volume.13 No. 2 p.81 ~ p.84
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Association between THSD4 Gene Polymorphisms and Hepatocellular Carcinoma in Korean Population
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Kim Su-Kang
Kang Sung-Wook
Kim Bum-Shik
Kim Keon-Sik
Chung Joo-Ho
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Abstract
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Hepatocellular carcinoma (HCC) is a hypervascular tumor characterized by neovascularization, which plays an important role in the growth and progression of cancer. This study assessed the association of thrombospondin, type I, domain containing 4 (THSD4) polymorphisms with HCC in Korean population. We selected three single nucleotide polymorphisms (SNPs) (rs961577, rs4777350, and rs2062651) in the THSD4 gene (heterozygosity＞0.1). SNP genotyping was conducted using a customized Illumina BeadChip and direct sequencing in 189 HCC patients and 386 control subjects in Korean population. For the analysis of data, EM algorithm, SNPStats, SNPAnalyzer, and Helixtree programs were used. Multiple logistic regression analysis with the codominant, dominant, and recessive models was performed. Statistical analysis revealed that a significant association (rs2062651) was found between HCC and controls. Our genetic result suggests that THSD4 may be associated with the development of HCC. (Cancer Prev Res 13, 81-84, 2008)
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KEYWORD
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Association, Hepatocellular carcinoma, Linkage disequilibrium, Polymorphism, Thrombospondin, type I, domain containing 4 (THSD4)
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